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As the name suggests, the SLC5 high-affinity choline transporter family contains high-affinity transporters, which are only expressed in cholinergic neurons and are essential for acetylcholine synthesis but not basal choline uptake (19)

Importantly, estrogen and hormone therapy are not prescribed as fat loss drugs

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The reduced precursors NRH and NMNH show promise in overcoming this, although preclinical evidence for health benefits is still limited, and whether their efficacy on functional readouts would be superior to the classic counterparts NR and NMN is also unclear

They also show promise in treating conditions such as fatty liver disease, obstructive sleep apnoea, and kidney disease

Golembiewska et al., 2013