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14 In pre-clinical research, formulations of tangerine peel not only inhibited insulin resistance and reduced hepatic lipid accumulation, but also improved markers of intestinal integrity and improved microbiota dysbiosis

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It was revealed that pretreatment with lixisenatide significantly suppressed elevation of inducible nitric oxide synthase (iNOS) and reversed the expression of endothelial nitric oxide synthase (eNOS) at the protein level and reduced mRNA of (NADPH oxidases 2) NOX2 in carotid arteries, which finally alleviated the endothelial dysfunction caused by ischemic/reperfusion (CI/R) in rats with diabetes more apparently than glimepiride (118)

In particular, the use of GLP-1RAs can break the vicious cycle of diabetes-depression [113]

You can also report suspected side effects via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)

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