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The biology behind it is not fully settled, but dose-response curves that peak and then fall off are common for signaling molecules, where too much of a stimulus can desensitize or overshoot the system it is meant to nudge

Either way, the peptides mentioned above have never passed that check

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Melanotan 2, which was created in the 1980s, has been found to boost lean body mass, decrease compulsive/addictive behavior, decrease compulsive behavior, and increase sexual desire

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