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Lancet Diabetes Endocrinol 2018;6:60517
Because it is so effective, you should start with a low dose to avoid going too far in the other direction (diarrhea)
The process of mixing these two is called reconstitution, and it's a critical step in proper drug administration
Male C57BL/6J mice (3545 g, 15- to 23-weeks-old) fed HFD, HFD-32 (CLEA Japan, 57% of total calorie from fat), for 40100 days were used as the mouse model of diet-induced obesity
The most common side effect at high doses (above 1,500mg IV) is transient mild hypotension or sulfur-related gastrointestinal discomfort