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A popular dual agonist, tirzepatide (Mounjaro), activates both GLP-1R and GIPR, producing synergistic effects on insulin secretion, appetite suppression, and weight reduction (Table 1)

GHK-Cu reduced inflammatory cytokines in certain tests, suggesting it may be beneficial in instances where inflammation and oxidative damage overlap, such as aging skin or metabolic stress [2]

in fact, some data suggest no difference

CJC-1295 (No DAC) acts on the GHRH receptor

Hepatol 70(1):e150e151

The skin tightening peptides may also be relevant, since significant weight loss often affects skin elasticity alongside hair health, and some compounds like GHK-Cu benefit both