38 As of December 31, 2025 CASH RUNWAY EXPECTED INTO 2028 $317M in cash, cash equivalents, and short-term investments THROUGH THE POTENTIAL APPROVAL ~110M shares outstanding AND LAUNCH OF AVEXITIDE IN 2027 39 Team Leadership Team Tenured in Rare Disease with Commercial and Clinical Development Capabilities Joshua Cohen, BSE Justin Klee, ScB Jim Frates Camille L
Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A (2013) Antagonistic crosstalk between NF-kB and SIRT1 in the regulation of inflammation and metabolic disorders
Preclinical studies in a nitroglycerin-induced migraine model using Sprague-Dawley rats demonstrated that Tianshu Capsule effectively modulated oxidative stress markers
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DEMOGRAPHIC ASPECT An extensive search of published case reports and review literatures on LHS since 1970 was performed based on the key words LaugierHunziker syndrome, Laugier-Hunziker-Baran syndrome, essential lenticular melanotic pigmentation, idiopathic lenticular mucocutaneous pigmentation, Laugier and Hunziker pigmentation, Laugiers disease, or longitudinal melanonychia. Most of the studies that were assessed and studied were in English