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found that while macaques immunized with a modified vaccinia Ankara viral vector expressing the SARS-CoV S protein had reduced viral replication after challenge, anti-S IgG also enhanced pulmonary infiltration of inflammatory macrophages and resulted in more severe lung injury compared to unvaccinated animals 66

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All the experiments and procedures were performed according to protocols approved by the Institutional Animal Care and Use Committee (IACUC) at City of Hope animal facilities (IACUC #15005)

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To view a copy of this licence, visit About this article Cite this article Rosenstock, J., Lingvay, I., Ryan, D