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The B55 subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation

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One influential if controversial explanation is that the increase reflects a socially contagious syndrome: Rapid Onset Gender Dysphoria. ROGD theoryproposes that common cultural beliefs, values, and preoccupations cause some adolescents (especially female adolescents) to attribute their social problems, feelings, and mental health issues to gender dysphoria, according to the article

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Alternatively, if acetylcysteine is not being utilized, then bicarbonate may be used to support the pH until pyroglutamic acid can be metabolized