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2021;147(3):100410 e2

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Disruptions in choline metabolism, whether due to impaired uptake or blockade of de novo PC synthesis by pharmacological inhibition of ChoK or CTP:phosphocholine cytidylyltransferase alpha (CCT), alter the cellular phospholipid pool composition, the integrity of the mitochondrial membrane, and the overall cellular activity, leading to immune dysfunction and dysregulated inflammation across species (67, 6972)