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doi: 10.1097/FPC.0b013e32832af5a3 55

10.1046/j.1471-4159.1995.64051965.x J

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None of the evidence reported in these papers is close to being convincing, and we would need extraordinary data to overcome the lack of plausibility for these patches working in the first place

"With the big pharma drugs, youre paying more up front, but as it goes up in dose, its actually cheaper." With compounded medications, a licensed pharmacist or physician combines, mixes or alters the ingredients to create a customized drug to meet a patients individual needs, but it is not FDA-approved, according to the agency

Such clarity is vital in experimental design, as it allows the focus to remain on pharmacology and outcomes rather than variability introduced by inconsistent schedules