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GLP-1R is expressed on neurons and glial cells across various brain regions [106]

DPP-4 has two mechanisms of action: first as a membrane spanning protein, where it binds and activates adenosine deaminase complexing protein and transfers intracellular signals via dimerization

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To reinforce the reliability of primary analyses, external validation was performed using data from the Chang Gung Research Database (CGRD) 55

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Research in the Journal of Nutritional Science shows curcumin directly stimulates GLP-1 secretion from intestinal L-cells