How Chemotherapy Causes Nerve Damage The exact mechanisms of CIPN are still being studied, but researchers have identified several ways chemotherapy can harm nerves: Direct Neurotoxicity: Chemotherapy drugs can damage the structure of nerves, including their protective coating (myelin)
Pollak 2008)
(54) found that administering GIPR antagonist to healthy humans reduced postprandial insulin secretion and increased glucose excursions more than administering GLP-1R antagonist (GLP-1RA), indicating that endogenous GIP may play a more significant role in stimulating insulin secretion and reducing postprandial plasma glucose excursions compared to endogenous GLP-1
Lott JP, Gross CP, Bosenberg M
"With Ozempic, it doesn't even matter now if you have a BMI of like 45
Thus, truncation of the C-terminal L585 residue of the GLP-1 fusion containing WT albumin reduces its cellular recycling in vitro and plasma half-life in vivo, which may be compensated for by QMP engineering of albumin, irrespective of the presence of L585