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blindness, limb amputation, neuropathy (loss of nerve function), nephropathy (loss of kidney function), heart attack, stroke, dementia, and sexual dysfunction

Diabetic neuropathy Peripheral neuropathy Up to 50% of diabetic patients develop peripheral neuropathy, a type of nerve damage that may result in pain, loss of sensation, and weakness, particularly in the lower extremities (67)

They bind to specific cell receptors and trigger targeted biological responses related to: Sexual function and arousal Hormone production Tissue repair Metabolism and mitochondrial health Mood and stress regulation Collagen production and skin health WHY DELIVERY ROUTE MATTERS Different peptides absorb through different pathways

Sulfate conjugation increases the hydrophilicity of drugs which are excreted from the body

Figlioli G, Piovani D, Peppas S, Pugliese N, Hassan C, Repici A, Lleo A, Aghemo A, Bonovas S

10.1073/pnas.1302107110 2 ArnoldL.EndersJ.ThomasS