Potential adverse reactions to these therapies could include headaches, dizziness, or fatigue for some individuals
Unlike genetic resistance, these phenotypes enable fungal cells to survive high concentrations of antifungals without a measurable increase in minimum inhibitory concentration (MIC), contributing to chronic and relapsing infections ( Cryptococcus can enter a quiescent state that confers high tolerance to AmB (Ke et al., 2024)
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Data extraction and risk of bias assessment One author (J.S.K.) used a standardized form to extract data from each included study, and a second author (G.L.) verified data accuracy and completeness (Supplementary Table 2)
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