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Within 10 years of T2DM diagnosis, 24.9% of people develop microalbuminuria, 5.3% develop macroalbuminuria, and 0.8% develop advanced CKD that includes persistently elevated plasma creatinine or the need for renal replacement therapy [4]

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G proteincoupled receptors (GPRs), including the aromatic amino acid sensor GPR142 (20) and the l-amino acidactivated calcium-sensing receptor (CaSR), may also mediate amino acid-induced glucagon (and insulin) secretion

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A non-inferiority RCT compared 295 T2D patients using 2 mg of EX-LAR weekly with 10 g of Exenatide twice daily for 30 weeks