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In a sample of 1,092 men and women without dementia followed for an average of 10 years, those with higher plasma homocysteine levels at baseline had a significantly higher risk of developing Alzheimer's disease and other types of dementia

The combined treatment led to significant improvements in migraine severity, duration, and frequency compared with either nutrient alone (Parohan 2021)

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Reviewers also assessed the methodology of each study, including the robustness of the study design and the validity of the results, to evaluate the overall quality of the scientific evidence