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Specifically, the generation of ceramides by dihydroceramide desaturase 1 (DES1) in adipocytes seems to impart some of the lipotoxic effects such as impaired glucose utilization, insulin resistance and hepatic steatosis (198)

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With increased stress, blood flow is diverted away from organs such as the bladder

Kharroubi AT, Darwish HM

For additional clinical context, see this article on copper tripeptide GHK-Cu in regenerative aesthetics