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GSH can directly quench free radicals and ROS while also serving as a cosubstrate for GPX in the conversion of hydrogen peroxide (H2O2) and lipid peroxide (Lipid-OOH) into water and lipid alcohol (Lipid-OH), respectively

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however, only a few cases of inter-individual microbiome variations have been documented [e.g., digoxin (Mathan et al., 1989) and acetaminophen (Clayton et al., 2009)]