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Overall, by integrating molecular insights with therapeutic advancements, we aim to provide a comprehensive understanding of UC pathogenesis and management, ultimately contributing to improved patient outcomes and quality of life

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So, RBCs cannot face oxidative stress because of the insufficient glutathione synthesis and the inefficient pentose phosphate pathway to produce NADPH, which leads to the irreversible oxidation of key structural and functional proteins such as hemoglobin, band 3, and peroxiredoxin 2 (Wither et al., 2016

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In addition, spearman correlation analysis indicated that GSTA4 mRNA expression was negatively correlated with DNA methylation levels in all individuals (r = .746, p .05, Figure 3F)