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The Surmount Clinical Development Program (Surmount-4 trial) enrolled 783 adults with obesity or overweight who did not have diabetes

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Thus, economic evaluations are necessary for the definition of rational drug use as they can provide cost and effectiveness evidence of competing therapies

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Against this backdrop, finding effective drugs for the pharmacological treatment of CVD has become one of the most urgent and challenging issues in medical research

For the cross-sectional study, plasma was removed and deproteinised with 6 % sulfosalicylic acid (1:1) to remove plasma proteins and enable reliable determination of free plasma CYS (Reference Trres, Miller and Rogers32)