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This study elucidates the non-selective activation mechanism by determining cryo-EM structures of Cagri bound to AMY 1 R-G s and CTR-G s complexes

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Other treatments that are sometimes recommended for melasma include chemical peels, laser treatments, and skin microneedling

Ethics declarations Ethics approval and consent to participate This study protocol was approved by the Ethics Committee of Shiraz University of Medical Sciences and performed in accordance with the Ethical Standards laid down in the 1964 Declaration of Helsinki and its later amendments

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Additionally, vitamin B12 is primarily found in animal products, such as meat and dairy products