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Annular Aortic Valve Enlargement Versus Transcatheter Aortic Valve Replacement in Women With Small Aortic Annulus: Contemporary Evidence, Challenges, and Future Directions

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[DOI] [PubMed] [Google Scholar] 48.Silva F.H., Alexandre E.C., Calmasini F.B., Calixto M.C., Antunes E

doi: 10.1038/s41467-022-28683-0 127 KnerrPJMowerySADourosJDPremdjeeBHjllundKRHeYet al

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Across all SGLT2i CVOTs, because of the quest for glycemic equipoise in the trials, the reduction in % HbA1c during the trial was modest at approximately 0.1% to 0.6%, indicating that glycemic control alone is unlikely to account for the cardiovascular benefit observed with use of this class of agents (62)