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The total daily energy expenditure remains stable between the ages of 20 to 60 years, then starts declining at an annual rate of 0.7% [8]

Another critical challenge involves the lack of standardized research methodologies, including inconsistency in dosing strategies, routes of administration, treatment durations, and outcome measures

10.1523/jneurosci.19-10-03952.1999 125 WrightJ.YamamotoB.HardingJ

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Morning fasted administration The most effective timing for AOD-9604 is morning administration in a fasted state