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Further investigations revealed that pachymic acid can lower serum insulin levels in DHEA-induced PCOS mice by regulating the CYP-17, IRS-1, and GLUT4 protein expression, thereby effectively improving IR within the ovarian tissues of these mice (75)

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Once-daily oral semaglutide was administered to test subjects diagnosed with type 2 diabetes in doses of either 2.5, 5, 10, 20, or 40 mg and compared to a placebo compound as well as a once-weekly subcutaneous administration of semaglutide