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Some of the direct demonstrations of paracellular permeability include autoradiography with 3 H polyethylene glycol (PEG) 400 (Da), which reported the presence of the marker molecule in the intercellular spaces, in the enterocytes, and interestingly, in a subset of goblet cells, foreshadowing the discovery of GAPs [26]

Keratoconus, in particular, is a degenerative ecstatic disease of the cornea that leads to bilateral visual impairment that is destined to worsen over time and for which there are no effective, non-invasive treatments

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