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AD patients also display additional biomarkers including cerebrovascular pathology and vascular dysfunctions, decreases in cerebral blood flow, cerebrovascular reactivity, and neurovascular coupling, leading to brain deficits in oxygen and nutrient delivery [4,5]

The majority of NTHi iron requirement is fulfilled by acquisition of haem therefore compounds that restrict haem-assimilation may have higher therapeutic value than those solely targeting iron acquisition

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