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Two major neuronal populations present in the arcuate nucleus control caloric intake and energy expenditure: one population co-expresses orexigenic agouti-related peptide (AgRP) and neuropeptide Y and the other expresses the anorexigenic anorectic neuropeptides proopiomelanocortin and cocaine- and amphetamine-regulated transcript (POMC/CART)

There are several possible hazards associated with this therapy, though the data on its advantages is scarce

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Tirzepatide (Mounjaro) has become a popular GLP-1 receptor agonist for weight loss, but pregnancy planning requires careful medical guidance

Large meals won't reduce the drug's effectiveness, but semaglutide makes eating large meals uncomfortablethe medication's purpose is to naturally limit portion size

10.1016/j.heliyon.2019.e02656 109 MugundhanV.ArthanariA.ParthasarathyP