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Based on Obesity Canada guidelines and clinical trials (typically over ~1 year): Saxenda: ~58% total body weight loss Wegovy: ~1015% total body weight loss Tirzepatide: ~1520% (or more) total body weight loss weight loss is gradual and occurs over several months, with the most significant changes seen after reaching the full therapeutic dose results vary depending on adherence, lifestyle factors, and individual response 7

In order to limit GLP-1 costs and prioritize the cohorts most at risk, payers should develop a risk stratification rubric to segment and prioritize patients for GLP-1 weight loss coverage in cases where it is medically necessary and/or where cost of care can be lowered the most

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