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Scientifically, aging reduces MC4R sensitivity and -MSH production, exacerbating HSDD, but activating these pathways can reverse the trend, with studies showing PT-141 boosts desire scores by up to 51% in affected women.[1][2] This is crucial post-40, as estrogen decline compounds neurological changes, leading to GSM and reduced dopamine release in reward centers

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10.1016/j.freeradbiomed.2022.06.004 [DOI] [PMC free article] [PubMed] [Google Scholar] Ingold I., Berndt C., Schmitt S., Doll S., Poschmann G., Buday K., et al

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