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The abdomen is still considered the most consistent option during early titration phases, but the thigh performs very well across the full dose range

A gradient-echo EPI sequence, TR = 1000 ms, TE = 13 ms, FOV = 20 7.9 mm 2 , slices: 13, slice thickness = 0.6 mm, matrix size = 121 48, repetitions = 480, was used to obtain resting state functional MRI (rs-fMRI) blood oxygen level-dependent (BOLD) data

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In a statement published alongside the results, Amgen said: Weight loss had not plateaued by 52 weeks, indicating the potential for further weight reduction. It added that improvements were recorded across other cardiometabolic measures, including waist circumference, blood pressure, high-sensitivity C-reactive protein (hs-CRP) and select lipid parameters