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It is not best suited for severe osteoarthritis, advanced cartilage loss, major joint deformity, complete tendon rupture, fracture, or injuries requiring surgical evaluation

CONCLUSION 1

Both peptides act as growth hormone secretagogues , meaning they stimulate the pituitary gland to release growth hormone without introducing synthetic GH into the body

Similarly, the evaluation of gastrointestinal symptoms such as nausea, vomiting, and diarrhea, which occur frequently with GLP-1RAs (42) and have a major influence on the adherence to such treatment over time, have often been assessed in clinical trials solely via participant self-report, which is known to be unrelaible (eg, symptoms may not be volunteered due to embarrassment or poor recall) (43, 44)