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Biomedicine & Pharmacotherapy, 127, 110137

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Clinical neuropathy has been reported in a 27-year old male with a MC4R gene mutation and morbid obesity, but this was attributed to the presence of T2DM ( We also show that 6 months of treatment with semaglutide was associated with small nerve fiber regeneration, but with a no major effect on weight, HbA1c and lipids, arguing for alternate mechanisms beyond an improvement in weight and glycemia as a basis for nerve regeneration in these two children with MC4R gene mutation

2024;26(1):e13841

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Other contributors may include mast-cell activation, allergy, chronic inflammation, medication effects or reduced intracellular breakdown by HNMT