T., Peng C., et al
Its a drug given to type 2 diabetics to lower their blood glucose levels, but its gotten quite popular among the biohacking scene More specifically, it decreases the production of glucose in the liver, decreases glucose uptake in the gut, and increases overall glucose utilization by improving insulin sensitivity in skeletal muscle Rhonda, personally, has never taken it Many claim metformin supplementation improves lifespan, but Findings have been skeptical in rodent models, with many variations among dose, gender, and dose timing (specifically, the age of the mouse when given the first treatment) Certain combinations of the above actually decrease lifespan, particularly in male mice Indeed, among type 2 diabetics, taking metformin improves lifespan, but if youre healthy, think twice Doesnt metformin reduce the risk of cancer
Long-term effects beyond 8-12 week cycles remain unknown due to the nature of available evidence
Curcuminoids have relatively poor bioavailability, and thus, various formulations and delivery methods, such as combining curcuminoids with black pepper extract (piperine) or using nanoparticle technology, are being explored to enhance their absorption and bioavailability [47]
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As such, early assessment and treatment of antioxidant status may result in a better prognosis as it could decrease the oxidative stress in the brain before it can induce more irreversible brain damage
