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Non-canonical pyroptosis is initiated by the detection of intracellular lipopolysaccharide (LPS) from Gram-negative bacteria, leading to the activation of caspase 4 (CASP4) and caspase 5 (CASP5) in humans and caspase 11 (CASP11) in mice, which cleave GSDMD independently of inflammasome assembly

It may also influence stem cell activity and protein synthesis related to tissue repair and hematopoiesis

PMCID: PMC5413479.

Available from Accessed 1 Mar 2023 Foster NC, Beck RW, Miller KM et al (2019) State of type 1 diabetes management and outcomes from the T1D exchange in 20162018

PloS One (2012) 7(7):e40561

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