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The core spliceosome as target and effector of non-canonical ATM signalling

Stabilized -catenin translocates to the nucleus and binds to transcription factors such as T cell factor and lymphoid enhancing factor (TCF/LEF), thus leading to the activation of target genes

These observations underscore the importance of altered epigenetic mechanisms in the complex pathophysiology of psoriasis and PsA (4042) and promise potential as diagnostic and/or prognostic biomarkers and future treatment targets

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doi: 10.14283/jfa.2018.45

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