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Another open-label phase Ib/II study is to evaluate the FGFR inhibitor, Debio 1347, with fulvestrant in patients with FGFR-amplified hormone receptor-positive metastatic breast cancer (NCT03344536)
doi: 10.1016/j.jtauto.2021.100101, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 8
Seoane J, Le HV, Shen L, Anderson SA, Massague J
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Some clinics use an intranasal formulation
In summary, while chemotherapy-induced senescence can be a significant aspect of cancer treatment, regulatory approval for these drugs is primarily contingent on their ability to effectively suppress tumor growth and improve clinical outcomes [56]
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