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The changes induce the production of pro-inflammatory cytokines such as tumor necrosis factor- (TNF-) and interleukins (IL-6 and IL-1), known as metabolic inflammation, which plays a significant part in insulin-resistant and type-2-diabetes mellitus subsequently

5,6 Without the appropriate GLP-1 activation, insulin is not released promptly, and glucagon production releases glucose into the bloodstream, contributing to elevated blood glucose levels

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