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Also at higher doses, it acts on centers in the brain and suppresses appetite

Concurrently, enhanced KP activity depletes TRP availability for 5-HT synthesis, weakening serotonergic inhibition of the amygdala, which in turn facilitates HPA axis activation [134]

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The development of related inhibitors also plays a role in TMAO regulation Animal experiments showed that inhibition of choline TMA lyase by 3,3-dimethyl-1-butanol (DMB) could reduce plasma TMAO levels and aortic lesions in mice

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