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doi:10.1210/jc.2006-1702 Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA

During OA, synovial tissue exhibits an inflammatory response, releasing IL-1, IL-6, TNF-, and other cytokines and chemokines that attract peripheral immune cells such as macrophages, neutrophils, and T cells to the synovial membrane (145, 146)

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[88] In addition to pre-meal dosing of GSK-1614235 producing delayed and reduced intestinal glucose absorption, the selective SGTL1 inhibitor also elevated GIP for 4 hours post-meal