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Overexpression of NLGN2 in adult mice leads to increased localization of GABAergic synaptic proteins at presynaptic and postsynaptic sites, associated with deficits in hippocampus-dependent behaviors and memory formation (84)

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1.2 10 5 SHSY-5Y cells were subjected to similar treatment as above except 1 mM MPP + (for 24 h) was used to induce ROS

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Drugs acting on the monoaminergic and opioid systems, such as bupropion-naltrexone and bupropion-zonisamide, are also being studied