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It is accepted that the following criteria should initiate the updating of an EHC monograph: new data are available that would substantially change the evaluation
Int J Biol Macromol 211:301315
Iron homeostasis in arthropathies: from pathogenesis to therapeutic potential
However, when ER stress is persistent and severe, UPR is insufficient to restore ER function, it promotes cell apoptosis by upregulating the expression of GADD153/CHOP, by activating caspase-12, and by inhibiting Bcl-2 expression
Gotthardt, D
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