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A background set of 11,744 brain-expressed proteins taken from a recent large-scale proteomic study was used for these analyses 13

It is a modification of amino acids 176-191

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doi: 10.1158/1078-0432.CCR-09-0265 338 Vanpouille-BoxCAlardAAryankalayilMJSarfrazYDiamondJMSchneiderRJet al

Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1