In its National Poison Data System alert, Americas Poison Centers noted that some people reported accidentally taking 10-times the recommended dose due to confusing measurement units while using a syringe. And people who are eager to lose extra weightbefore a wedding or a vacation, for examplemay choose to self-administer a higher-than-recommended dose, said Arthur Caplan, a bioethics professor at New York Universitys Grossman School of Medicine
Given the increasing emphasis on the use of GLP-1 RAs in clinical practice, it is important that all members of the healthcare team, including pharmacy professionals, understand current recommendations and patient-specific considerations for use
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It will be interesting to assess whether this action of GLP-1 is selective for glucose-responsive neurons in the Arc and whether the inhibition of K ATP channel activity results from Epac2 activation, as described for -cells
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