Metabolomic studies on patients with PKU have demonstrated elevated serum levels of phenylalanine derivatives, including phenylpyruvate, phenylacetate, phenyllactate, mandelic acid, 4-hydroxyphenylacetic acid, and several others (54, 55)
Preclinical combination studies confirm that simultaneous GLP-1R and GIPR activation outperforms either receptor alone for weight reduction and glycemic control
Distinct epigenetic signatures between adult-onset and late-onset depression
Morris G, Puri BK, Bortolasci CC, et al
Side effects Common side effects associated with both Tirzepatide and Semaglutide include gastrointestinal symptoms such as nausea, vomiting, and diarrhea
Figure 1 IMDs should be suspected particularly in children presenting with combined endocrinopathies