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In the STEP-HFpEF trial of participants with the obesity phenotype of HFpEF, semaglutide improved symptoms, physical limitations and exercise function and reduced inflammation and body weight across the spectrum of obesity categories

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WD increased inflammation in a sex- and region-specific manner, and GE2 reduced inflammation in the hippocampus in SD-fed rats, as well as in the amygdala of males regardless of diet Brain aging is associated with increased inflammation, however diets, such as the WD, may further affect inflammation