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The synthesis of NAC with pharmacologic agents that adjust metabolic or inflammatory pathways will be capable of producing maximum therapeutic potential

Cagrilintides gastric effect is inferred with reasonable confidence from receptor pharmacology, animal data, and its gastrointestinal side-effect profile, but published monotherapy trials did not center on validated gastric-emptying measurements (scintigraphy or breath testing) tracked over time

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26 advise based on mouse models with TN-X deficiency to monitor clEDS patients closely during pregnancy, as they are likely to have weaker genitourinary (GU) connective tissue and could therefore be at risk of GU complications

Trends in Molecular Medicine, 28 (1), 36-50

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