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Studies indicate that alcohol-induced oxidative stress plays an important role in liver damage, mainly through activation of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase and cytochrome P450 2E1 (CYP2E1), which leads to an overproduction of reactive oxygen species (ROS) [35]

Hasler G, Drevets WC, Manji HK, Charney DS

By the rearrangement, the hydroxyl group of the substrate is placed in an equatorial position, allowing the electrophilic attack to the aromatic ring by the Cu 2 O 2 oxidant

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