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Dopaminergic neurons in the substantia nigra , the brain region most affected by Parkinson's disease, express receptors for an inflammatory cytokine called tumor necrosis factor-alpha (TNF-) , which suggests that excess TNF- released by nearby activated microglia may damage nigral dopaminergic cells

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Smooth muscle-expressed ORs demonstrate exquisite environmental sensitivity, modulating airway tone through multiple signaling cascades