how to transition from tirzepatide to semaglutide Switching Semaglutide: Clinical Guide – PlexusDx Switching from Semaglutide to Tirzepatide:

Dulaglutide is not directly associated with kidney damage, but side effects such as vomiting or diarrhoea may lead to dehydration, which can strain kidney function

The interesting part is that applying it to skin in a cream has real clinical evidence behind it

10.1038/s41467-023-35828-2 7 HuS.QinD.MengS.WuY.LuoZ.DengB

However, more recent large studies have shown that while niacin can lower LDL cholesterol, taking it with a statin does not reduce the risk of CVD or stroke

When endogenous insulin production is insufficient to compensate for increasing insulin resistance, serum glucose levels go up leading to a pre-diabetic state (fasting glucose levels of 100125 mg/dL and A1C 5.76.4%) and consequently to diabetes (fasting glucose levels 126 mg/dL and A1C 6.5%) (50, 65)

The key is knowing what these injections can actually do versus what you might be hoping they'll do