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Galectin-3 is an ~30 kDa protein and contains a carbohydrate recognition binding domain of ~130 amino acids that enables the specific binding of -galactosidases

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56 Small molecule targeted therapy (BRAF and MEK inhibitors) and immune checkpoint inhibitors (CTLA4 and PD1) have shown promising clinical outcomes

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Grade-specific expression of insulin-like growth factor-binding proteins-2, -3, and -5 in astrocytomas: IGFBP-3 emerges as a strong predictor of survival in patients with newly diagnosed glioblastoma